Abstract
Synthesis and activity of a series of 4-thiazol-yl substituted analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been disclosed.
MeSH terms
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Animals
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Carbazoles / chemical synthesis*
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Carbazoles / pharmacology*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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PC12 Cells
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Poly (ADP-Ribose) Polymerase-1
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Poly(ADP-ribose) Polymerase Inhibitors*
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Rats
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Recombinant Proteins / antagonists & inhibitors
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Structure-Activity Relationship
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology*
Substances
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4-thiazol-yl pyrrolocarbazole
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Carbazoles
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Enzyme Inhibitors
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Indicators and Reagents
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Poly(ADP-ribose) Polymerase Inhibitors
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Recombinant Proteins
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Thiazoles
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PARP1 protein, human
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Parp1 protein, rat
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Poly (ADP-Ribose) Polymerase-1